The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Identifieur interne : 000542 ( Main/Corpus ); précédent : 000541; suivant : 000543The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Auteurs : Paolo Barone ; Angelo Antonini ; Carlo Colosimo ; Roberto Marconi ; Letterio Morgante ; Tania P. Avarello ; Eugenio Bottacchi ; Antonino Cannas ; Gabriella Ceravolo ; Roberto Ceravolo ; Giulio Cicarelli ; Roberto M. Gaglio ; Rosa M. Giglia ; Francesco Iemolo ; Michela Manfredi ; Giuseppe Meco ; Alessandra Nicoletti ; Massimo Pederzoli ; Alfredo Petrone ; Antonio Pisani ; Francesco E. Pontieri ; Rocco Quatrale ; Silvia Ramat ; Rosanna Scala ; Giuseppe Volpe ; Salvatore Zappulla ; Anna Rita Bentivoglio ; Fabrizio Stocchi ; Giorgio Trianni ; Paolo Del DottoSource :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
English descriptors
Abstract
We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22643
Links to Exploration step
ISTEX:C2707E76FBB6EAF18B68003488BBC42442387A40Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation><mods:affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation><mods:affiliation>Neurologia, Ospedale della Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Avarello, Tania P" sort="Avarello, Tania P" uniqKey="Avarello T" first="Tania P." last="Avarello">Tania P. Avarello</name><affiliation><mods:affiliation>Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bottacchi, Eugenio" sort="Bottacchi, Eugenio" uniqKey="Bottacchi E" first="Eugenio" last="Bottacchi">Eugenio Bottacchi</name><affiliation><mods:affiliation>U.O. di Neurologia, Ospedale Regionale, Aosta, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cannas, Antonino" sort="Cannas, Antonino" uniqKey="Cannas A" first="Antonino" last="Cannas">Antonino Cannas</name><affiliation><mods:affiliation>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Gabriella" sort="Ceravolo, Gabriella" uniqKey="Ceravolo G" first="Gabriella" last="Ceravolo">Gabriella Ceravolo</name><affiliation><mods:affiliation>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation><mods:affiliation>Neurologia, Ospedale Santa Chiara, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name><affiliation><mods:affiliation>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gaglio, Roberto M" sort="Gaglio, Roberto M" uniqKey="Gaglio R" first="Roberto M." last="Gaglio">Roberto M. Gaglio</name><affiliation><mods:affiliation>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy</mods:affiliation></affiliation></author><author><name sortKey="Giglia, Rosa M" sort="Giglia, Rosa M" uniqKey="Giglia R" first="Rosa M." last="Giglia">Rosa M. Giglia</name><affiliation><mods:affiliation>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy</mods:affiliation></affiliation></author><author><name sortKey="Iemolo, Francesco" sort="Iemolo, Francesco" uniqKey="Iemolo F" first="Francesco" last="Iemolo">Francesco Iemolo</name><affiliation><mods:affiliation>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><affiliation><mods:affiliation>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova, Italy</mods:affiliation></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation><mods:affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation><mods:affiliation>Clinica Neurologica I, Policlinico Universitario, Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pederzoli, Massimo" sort="Pederzoli, Massimo" uniqKey="Pederzoli M" first="Massimo" last="Pederzoli">Massimo Pederzoli</name><affiliation><mods:affiliation>Neurologia, Ospedale Civile, Vimercate, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name><affiliation><mods:affiliation>Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pisani, Antonio" sort="Pisani, Antonio" uniqKey="Pisani A" first="Antonio" last="Pisani">Antonio Pisani</name><affiliation><mods:affiliation>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pontieri, Francesco E" sort="Pontieri, Francesco E" uniqKey="Pontieri F" first="Francesco E." last="Pontieri">Francesco E. Pontieri</name><affiliation><mods:affiliation>Ospedale Sant'Andrea, Universitá La Sapienza, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quatrale, Rocco" sort="Quatrale, Rocco" uniqKey="Quatrale R" first="Rocco" last="Quatrale">Rocco Quatrale</name><affiliation><mods:affiliation>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze, Italy</mods:affiliation></affiliation></author><author><name sortKey="Scala, Rosanna" sort="Scala, Rosanna" uniqKey="Scala R" first="Rosanna" last="Scala">Rosanna Scala</name><affiliation><mods:affiliation>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Volpe, Giuseppe" sort="Volpe, Giuseppe" uniqKey="Volpe G" first="Giuseppe" last="Volpe">Giuseppe Volpe</name><affiliation><mods:affiliation>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy</mods:affiliation></affiliation></author><author><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name><affiliation><mods:affiliation>Neurologia, Ospedale Umberto I, Enna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><mods:affiliation>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation><mods:affiliation>IRCCS San Raffaele, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Trianni, Giorgio" sort="Trianni, Giorgio" uniqKey="Trianni G" first="Giorgio" last="Trianni">Giorgio Trianni</name><affiliation><mods:affiliation>Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name><affiliation><mods:affiliation>U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C2707E76FBB6EAF18B68003488BBC42442387A40</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22643</idno><idno type="url">https://api.istex.fr/document/C2707E76FBB6EAF18B68003488BBC42442387A40/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation><mods:affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation><mods:affiliation>Neurologia, Ospedale della Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Avarello, Tania P" sort="Avarello, Tania P" uniqKey="Avarello T" first="Tania P." last="Avarello">Tania P. Avarello</name><affiliation><mods:affiliation>Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bottacchi, Eugenio" sort="Bottacchi, Eugenio" uniqKey="Bottacchi E" first="Eugenio" last="Bottacchi">Eugenio Bottacchi</name><affiliation><mods:affiliation>U.O. di Neurologia, Ospedale Regionale, Aosta, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cannas, Antonino" sort="Cannas, Antonino" uniqKey="Cannas A" first="Antonino" last="Cannas">Antonino Cannas</name><affiliation><mods:affiliation>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Gabriella" sort="Ceravolo, Gabriella" uniqKey="Ceravolo G" first="Gabriella" last="Ceravolo">Gabriella Ceravolo</name><affiliation><mods:affiliation>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation><mods:affiliation>Neurologia, Ospedale Santa Chiara, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name><affiliation><mods:affiliation>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gaglio, Roberto M" sort="Gaglio, Roberto M" uniqKey="Gaglio R" first="Roberto M." last="Gaglio">Roberto M. Gaglio</name><affiliation><mods:affiliation>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy</mods:affiliation></affiliation></author><author><name sortKey="Giglia, Rosa M" sort="Giglia, Rosa M" uniqKey="Giglia R" first="Rosa M." last="Giglia">Rosa M. Giglia</name><affiliation><mods:affiliation>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy</mods:affiliation></affiliation></author><author><name sortKey="Iemolo, Francesco" sort="Iemolo, Francesco" uniqKey="Iemolo F" first="Francesco" last="Iemolo">Francesco Iemolo</name><affiliation><mods:affiliation>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><affiliation><mods:affiliation>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova, Italy</mods:affiliation></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation><mods:affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation><mods:affiliation>Clinica Neurologica I, Policlinico Universitario, Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pederzoli, Massimo" sort="Pederzoli, Massimo" uniqKey="Pederzoli M" first="Massimo" last="Pederzoli">Massimo Pederzoli</name><affiliation><mods:affiliation>Neurologia, Ospedale Civile, Vimercate, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name><affiliation><mods:affiliation>Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pisani, Antonio" sort="Pisani, Antonio" uniqKey="Pisani A" first="Antonio" last="Pisani">Antonio Pisani</name><affiliation><mods:affiliation>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pontieri, Francesco E" sort="Pontieri, Francesco E" uniqKey="Pontieri F" first="Francesco E." last="Pontieri">Francesco E. Pontieri</name><affiliation><mods:affiliation>Ospedale Sant'Andrea, Universitá La Sapienza, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quatrale, Rocco" sort="Quatrale, Rocco" uniqKey="Quatrale R" first="Rocco" last="Quatrale">Rocco Quatrale</name><affiliation><mods:affiliation>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze, Italy</mods:affiliation></affiliation></author><author><name sortKey="Scala, Rosanna" sort="Scala, Rosanna" uniqKey="Scala R" first="Rosanna" last="Scala">Rosanna Scala</name><affiliation><mods:affiliation>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Volpe, Giuseppe" sort="Volpe, Giuseppe" uniqKey="Volpe G" first="Giuseppe" last="Volpe">Giuseppe Volpe</name><affiliation><mods:affiliation>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy</mods:affiliation></affiliation></author><author><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name><affiliation><mods:affiliation>Neurologia, Ospedale Umberto I, Enna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><mods:affiliation>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation><mods:affiliation>IRCCS San Raffaele, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Trianni, Giorgio" sort="Trianni, Giorgio" uniqKey="Trianni G" first="Giorgio" last="Trianni">Giorgio Trianni</name><affiliation><mods:affiliation>Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name><affiliation><mods:affiliation>U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1641">1641</biblScope><biblScope unit="page" to="1649">1649</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C2707E76FBB6EAF18B68003488BBC42442387A40</idno><idno type="DOI">10.1002/mds.22643</idno><idno type="ArticleID">MDS22643</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>nonmotor symptoms</term><term>psychiatric symptoms</term><term>quality of life</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Paolo Barone MD</name><affiliations><json:string>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Angelo Antonini MD</name><affiliations><json:string>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</json:string></affiliations></json:item><json:item><name>Carlo Colosimo MD</name><affiliations><json:string>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</json:string></affiliations></json:item><json:item><name>Roberto Marconi MD</name><affiliations><json:string>Neurologia, Ospedale della Misericordia, Grosseto, Italy</json:string></affiliations></json:item><json:item><name>Letterio Morgante MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Italy</json:string></affiliations></json:item><json:item><name>Tania P. Avarello MD</name><affiliations><json:string>Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Eugenio Bottacchi MD</name><affiliations><json:string>U.O. di Neurologia, Ospedale Regionale, Aosta, Italy</json:string></affiliations></json:item><json:item><name>Antonino Cannas MD</name><affiliations><json:string>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy</json:string></affiliations></json:item><json:item><name>Gabriella Ceravolo MD</name><affiliations><json:string>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy</json:string></affiliations></json:item><json:item><name>Roberto Ceravolo MD</name><affiliations><json:string>Neurologia, Ospedale Santa Chiara, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Giulio Cicarelli MD</name><affiliations><json:string>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy</json:string></affiliations></json:item><json:item><name>Roberto M. Gaglio MD</name><affiliations><json:string>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy</json:string></affiliations></json:item><json:item><name>Rosa M. Giglia MD</name><affiliations><json:string>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy</json:string></affiliations></json:item><json:item><name>Francesco Iemolo MD</name><affiliations><json:string>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy</json:string></affiliations></json:item><json:item><name>Michela Manfredi MD</name><affiliations><json:string>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova, Italy</json:string></affiliations></json:item><json:item><name>Giuseppe Meco MD</name><affiliations><json:string>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</json:string></affiliations></json:item><json:item><name>Alessandra Nicoletti MD</name><affiliations><json:string>Clinica Neurologica I, Policlinico Universitario, Catania, Italy</json:string></affiliations></json:item><json:item><name>Massimo Pederzoli MD</name><affiliations><json:string>Neurologia, Ospedale Civile, Vimercate, Milano, Italy</json:string></affiliations></json:item><json:item><name>Alfredo Petrone MD</name><affiliations><json:string>Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Antonio Pisani MD</name><affiliations><json:string>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma, Italy</json:string></affiliations></json:item><json:item><name>Francesco E. Pontieri MD</name><affiliations><json:string>Ospedale Sant'Andrea, Universitá La Sapienza, Roma, Italy</json:string></affiliations></json:item><json:item><name>Rocco Quatrale MD</name><affiliations><json:string>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara, Italy</json:string></affiliations></json:item><json:item><name>Silvia Ramat MD</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze, Italy</json:string></affiliations></json:item><json:item><name>Rosanna Scala MD</name><affiliations><json:string>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Giuseppe Volpe MD</name><affiliations><json:string>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy</json:string></affiliations></json:item><json:item><name>Salvatore Zappulla MD</name><affiliations><json:string>Neurologia, Ospedale Umberto I, Enna, Italy</json:string></affiliations></json:item><json:item><name>Anna Rita Bentivoglio MD</name><affiliations><json:string>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma, Italy</json:string></affiliations></json:item><json:item><name>Fabrizio Stocchi MD</name><affiliations><json:string>IRCCS San Raffaele, Roma, Italy</json:string></affiliations></json:item><json:item><name>Giorgio Trianni MD</name><affiliations><json:string>Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy</json:string></affiliations></json:item><json:item><name>Paolo Del Dotto MD</name><affiliations><json:string>U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>nonmotor symptoms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quality of life</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>psychiatric symptoms</value></json:item></subject><articleId><json:string>MDS22643</json:string></articleId><language><json:string>eng</json:string></language><abstract>We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>7.078</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1258</abstractCharCount><pdfWordCount>4798</pdfWordCount><pdfCharCount>32656</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>190</abstractWordCount></qualityIndicators><title>The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>9</total><last>1649</last><first>1641</first></pages><issn><json:string>0885-3185</json:string></issn><issue>11</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22643</json:string></doi><id>C2707E76FBB6EAF18B68003488BBC42442387A40</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C2707E76FBB6EAF18B68003488BBC42442387A40/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C2707E76FBB6EAF18B68003488BBC42442387A40/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C2707E76FBB6EAF18B68003488BBC42442387A40/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Members of the “PRIAMO Study Group” are listed as an Appendix. Potential conflict of interest: Angelo Antonini, Paolo Barone, Carlo Colosimo, Roberto Marconi, and Letterio Morgante have received consultancy fees from Boehringer‐Ingelheim, Italy.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD</roleName><affiliation>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli, Italy</affiliation></author><author><persName><forename type="first">Angelo</forename><surname>Antonini</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Parkinson Institute, Via Bignami, 1, I‐20126 Milan, Italy</p></note><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</affiliation></author><author><persName><forename type="first">Carlo</forename><surname>Colosimo</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Marconi</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Ospedale della Misericordia, Grosseto, Italy</affiliation></author><author><persName><forename type="first">Letterio</forename><surname>Morgante</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Italy</affiliation></author><author><persName><forename type="first">Tania P.</forename><surname>Avarello</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy</affiliation></author><author><persName><forename type="first">Eugenio</forename><surname>Bottacchi</surname></persName><roleName type="degree">MD</roleName><affiliation>U.O. di Neurologia, Ospedale Regionale, Aosta, Italy</affiliation></author><author><persName><forename type="first">Antonino</forename><surname>Cannas</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy</affiliation></author><author><persName><forename type="first">Gabriella</forename><surname>Ceravolo</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Ceravolo</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Ospedale Santa Chiara, Pisa, Italy</affiliation></author><author><persName><forename type="first">Giulio</forename><surname>Cicarelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy</affiliation></author><author><persName><forename type="first">Roberto M.</forename><surname>Gaglio</surname></persName><roleName type="degree">MD</roleName><affiliation>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy</affiliation></author><author><persName><forename type="first">Rosa M.</forename><surname>Giglia</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy</affiliation></author><author><persName><forename type="first">Francesco</forename><surname>Iemolo</surname></persName><roleName type="degree">MD</roleName><affiliation>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy</affiliation></author><author><persName><forename type="first">Michela</forename><surname>Manfredi</surname></persName><roleName type="degree">MD</roleName><affiliation>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova, Italy</affiliation></author><author><persName><forename type="first">Giuseppe</forename><surname>Meco</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</affiliation></author><author><persName><forename type="first">Alessandra</forename><surname>Nicoletti</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica Neurologica I, Policlinico Universitario, Catania, Italy</affiliation></author><author><persName><forename type="first">Massimo</forename><surname>Pederzoli</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Ospedale Civile, Vimercate, Milano, Italy</affiliation></author><author><persName><forename type="first">Alfredo</forename><surname>Petrone</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy</affiliation></author><author><persName><forename type="first">Antonio</forename><surname>Pisani</surname></persName><roleName type="degree">MD</roleName><affiliation>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma, Italy</affiliation></author><author><persName><forename type="first">Francesco E.</forename><surname>Pontieri</surname></persName><roleName type="degree">MD</roleName><affiliation>Ospedale Sant'Andrea, Universitá La Sapienza, Roma, Italy</affiliation></author><author><persName><forename type="first">Rocco</forename><surname>Quatrale</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara, Italy</affiliation></author><author><persName><forename type="first">Silvia</forename><surname>Ramat</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze, Italy</affiliation></author><author><persName><forename type="first">Rosanna</forename><surname>Scala</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli, Italy</affiliation></author><author><persName><forename type="first">Giuseppe</forename><surname>Volpe</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy</affiliation></author><author><persName><forename type="first">Salvatore</forename><surname>Zappulla</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, Ospedale Umberto I, Enna, Italy</affiliation></author><author><persName><forename type="first">Anna Rita</forename><surname>Bentivoglio</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma, Italy</affiliation></author><author><persName><forename type="first">Fabrizio</forename><surname>Stocchi</surname></persName><roleName type="degree">MD</roleName><affiliation>IRCCS San Raffaele, Roma, Italy</affiliation></author><author><persName><forename type="first">Giorgio</forename><surname>Trianni</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy</affiliation></author><author><persName><forename type="first">Paolo Del</forename><surname>Dotto</surname></persName><roleName type="degree">MD</roleName><affiliation>U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1641">1641</biblScope><biblScope unit="page" to="1649">1649</biblScope></imprint></monogr><idno type="istex">C2707E76FBB6EAF18B68003488BBC42442387A40</idno><idno type="DOI">10.1002/mds.22643</idno><idno type="ArticleID">MDS22643</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>nonmotor symptoms</term></item><item><term>Parkinson's disease</term></item><item><term>quality of life</term></item><item><term>cognition</term></item><item><term>psychiatric symptoms</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-01-19">Received</change><change when="2009-04-04">Registration</change><change when="2009-08-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C2707E76FBB6EAF18B68003488BBC42442387A40/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="110"><doi origin="wiley" registered="yes">10.1002/mds.v24:11</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">11</numbering></numberingGroup><coverDate startDate="2009-08-15">15 August 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="120" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22643</doi><idGroup><id type="unit" value="MDS22643"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-01-19"></event><event type="manuscriptRevised" date="2009-03-30"></event><event type="manuscriptAccepted" date="2009-04-04"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-06-09"></event><event type="firstOnline" date="2009-06-09"></event><event type="publishedOnlineFinalForm" date="2009-08-26"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1641</numbering><numbering type="pageLast">1649</numbering></numberingGroup><correspondenceTo>Parkinson Institute, Via Bignami, 1, I‐20126 Milan, Italy</correspondenceTo><objectNameGroup><objectName elementName="appendix">APPENDIX</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22643.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="34"></count><count type="wordTotal" number="6412"></count></countGroup><titleGroup><title type="main" xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Nonmotor Symptoms in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Angelo</givenNames><familyName>Antonini</familyName><degrees>MD</degrees></personName><contactDetails><email>angelo3000@yahoo.com</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Carlo</givenNames><familyName>Colosimo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Roberto</givenNames><familyName>Marconi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Letterio</givenNames><familyName>Morgante</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Tania P.</givenNames><familyName>Avarello</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Eugenio</givenNames><familyName>Bottacchi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Antonino</givenNames><familyName>Cannas</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Gabriella</givenNames><familyName>Ceravolo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Roberto</givenNames><familyName>Ceravolo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Giulio</givenNames><familyName>Cicarelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Roberto M.</givenNames><familyName>Gaglio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af13"><personName><givenNames>Rosa M.</givenNames><familyName>Giglia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af14"><personName><givenNames>Francesco</givenNames><familyName>Iemolo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af15"><personName><givenNames>Michela</givenNames><familyName>Manfredi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Giuseppe</givenNames><familyName>Meco</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af16"><personName><givenNames>Alessandra</givenNames><familyName>Nicoletti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af17"><personName><givenNames>Massimo</givenNames><familyName>Pederzoli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au19" creatorRole="author" affiliationRef="#af18"><personName><givenNames>Alfredo</givenNames><familyName>Petrone</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au20" creatorRole="author" affiliationRef="#af19"><personName><givenNames>Antonio</givenNames><familyName>Pisani</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au21" creatorRole="author" affiliationRef="#af20"><personName><givenNames>Francesco E.</givenNames><familyName>Pontieri</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au22" creatorRole="author" affiliationRef="#af21"><personName><givenNames>Rocco</givenNames><familyName>Quatrale</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au23" creatorRole="author" affiliationRef="#af22"><personName><givenNames>Silvia</givenNames><familyName>Ramat</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au24" creatorRole="author" affiliationRef="#af23"><personName><givenNames>Rosanna</givenNames><familyName>Scala</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au25" creatorRole="author" affiliationRef="#af24"><personName><givenNames>Giuseppe</givenNames><familyName>Volpe</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au26" creatorRole="author" affiliationRef="#af25"><personName><givenNames>Salvatore</givenNames><familyName>Zappulla</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au27" creatorRole="author" affiliationRef="#af26"><personName><givenNames>Anna Rita</givenNames><familyName>Bentivoglio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au28" creatorRole="author" affiliationRef="#af27"><personName><givenNames>Fabrizio</givenNames><familyName>Stocchi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au29" creatorRole="author" affiliationRef="#af28"><personName><givenNames>Giorgio</givenNames><familyName>Trianni</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au30" creatorRole="author" affiliationRef="#af29"><personName><givenNames>Paolo Del</givenNames><familyName>Dotto</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Ospedale della Misericordia, Grosseto, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="IT" type="organization"><unparsedAffiliation>U.O. di Neurologia, Ospedale Regionale, Aosta, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="IT" type="organization"><unparsedAffiliation>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="IT" type="organization"><unparsedAffiliation>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Ospedale Santa Chiara, Pisa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af12" countryCode="IT" type="organization"><unparsedAffiliation>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="IT" type="organization"><unparsedAffiliation>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="IT" type="organization"><unparsedAffiliation>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af16" countryCode="IT" type="organization"><unparsedAffiliation>Clinica Neurologica I, Policlinico Universitario, Catania, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af17" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Ospedale Civile, Vimercate, Milano, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af18" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af19" countryCode="IT" type="organization"><unparsedAffiliation>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af20" countryCode="IT" type="organization"><unparsedAffiliation>Ospedale Sant'Andrea, Universitá La Sapienza, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af21" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af22" countryCode="IT" type="organization"><unparsedAffiliation>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af23" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af24" countryCode="IT" type="organization"><unparsedAffiliation>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af25" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, Ospedale Umberto I, Enna, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af26" countryCode="IT" type="organization"><unparsedAffiliation>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af27" countryCode="IT" type="organization"><unparsedAffiliation>IRCCS San Raffaele, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af28" countryCode="IT" type="organization"><unparsedAffiliation>Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af29" countryCode="IT" type="organization"><unparsedAffiliation>U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">nonmotor symptoms</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">quality of life</keyword><keyword xml:id="kwd4">cognition</keyword><keyword xml:id="kwd5">psychiatric symptoms</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Members of the “PRIAMO Study Group” are listed as an <link href="#app1">Appendix</link>.</p><p>Potential conflict of interest: Angelo Antonini, Paolo Barone, Carlo Colosimo, Roberto Marconi, and Letterio Morgante have received consultancy fees from Boehringer‐Ingelheim, Italy.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Nonmotor Symptoms in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angelo</namePart><namePart type="family">Antonini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</affiliation><description>Correspondence: Parkinson Institute, Via Bignami, 1, I‐20126 Milan, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Colosimo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Marconi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Ospedale della Misericordia, Grosseto, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Letterio</namePart><namePart type="family">Morgante</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tania P.</namePart><namePart type="family">Avarello</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugenio</namePart><namePart type="family">Bottacchi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>U.O. di Neurologia, Ospedale Regionale, Aosta, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonino</namePart><namePart type="family">Cannas</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gabriella</namePart><namePart type="family">Ceravolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Ceravolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Ospedale Santa Chiara, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giulio</namePart><namePart type="family">Cicarelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto M.</namePart><namePart type="family">Gaglio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosa M.</namePart><namePart type="family">Giglia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesco</namePart><namePart type="family">Iemolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michela</namePart><namePart type="family">Manfredi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Meco</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandra</namePart><namePart type="family">Nicoletti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica I, Policlinico Universitario, Catania, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Massimo</namePart><namePart type="family">Pederzoli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Ospedale Civile, Vimercate, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfredo</namePart><namePart type="family">Petrone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Pisani</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesco E.</namePart><namePart type="family">Pontieri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Ospedale Sant'Andrea, Universitá La Sapienza, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rocco</namePart><namePart type="family">Quatrale</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silvia</namePart><namePart type="family">Ramat</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosanna</namePart><namePart type="family">Scala</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Volpe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Salvatore</namePart><namePart type="family">Zappulla</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, Ospedale Umberto I, Enna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna Rita</namePart><namePart type="family">Bentivoglio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabrizio</namePart><namePart type="family">Stocchi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>IRCCS San Raffaele, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giorgio</namePart><namePart type="family">Trianni</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo Del</namePart><namePart type="family">Dotto</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>U.O. di Neurologia, Ospedale Versilia, Camaiore, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-08-15</dateIssued><dateCaptured encoding="w3cdtf">2009-01-19</dateCaptured><dateValid encoding="w3cdtf">2009-04-04</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">34</extent><extent unit="words">6412</extent></physicalDescription><abstract lang="en">We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society</abstract><note type="content">*Members of the “PRIAMO Study Group” are listed as an Appendix. Potential conflict of interest: Angelo Antonini, Paolo Barone, Carlo Colosimo, Roberto Marconi, and Letterio Morgante have received consultancy fees from Boehringer‐Ingelheim, Italy.</note><subject lang="en"><genre>Keywords</genre><topic>nonmotor symptoms</topic><topic>Parkinson's disease</topic><topic>quality of life</topic><topic>cognition</topic><topic>psychiatric symptoms</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1641</start><end>1649</end><total>9</total></extent></part></relatedItem><identifier type="istex">C2707E76FBB6EAF18B68003488BBC42442387A40</identifier><identifier type="DOI">10.1002/mds.22643</identifier><identifier type="ArticleID">MDS22643</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000542 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000542 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:C2707E76FBB6EAF18B68003488BBC42442387A40
|texte= The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |